Prompt cytomolecular identification of chromosome aberration in irradiated blood cells

Pharmaceutical effluent induced chromosome aberration in rat bone marrow cells

This paper presents the genotoxic effect of effluent from a pharmaceutical plant in Ota, Ogun state, Nigeria using the rat bone-marrow metaphase chromosome assay. The effluent was examined for some standard physical and chemical properties. Rats were intraperitoneally exposed to 1%, 5%, 10%, 25% and 50% (v/v, effluent/distilled water) concentrations of the effluent for 48 hr. Distilled water an...

Comparison of chromosome aberration frequencies in pre- and post-flight astronaut lymphocytes irradiated in vitro with gamma rays.

If radiosensitivity is altered in a microgravity environment, it will affect the accuracy of assessing astronauts' risk from exposure to space radiation. To investigate the effects of space flight on radiosensitivity, we exposed a crewmember's blood to gamma rays at doses ranging from 0 to 3 Gy and analyzed chromosome aberrations in mitotic lymphocytes. The blood samples were collected 10 days ...

Rare chromosome structural aberration characterizing oncology malignancy.

UNLABELLED Ring chromosome aberration are rare abnormality potentially involving any chromosome in patients diagnosing in Oncology. The present review and case study has focused on the ring chromosome associated with oncology malignancies. MATERIAL AND METHODS An electronic peer review article search was performed systematically to obtain relevant literature with the CINAHL, Google scholar, a...

Persistent chromosome aberrations in irradiated human subjects.

Bystander responses in low dose irradiated cells treated with plasma from gamma irradiated blood

A number of studies in the field of radiobiology contradict the Linear Non-Threshold model in the low dose range. These observations indicate that there may be more harmful effects for cells exposed to low dose irradiation than would be predicted by extrapolation from high dose data. For the last 20 years a new phenomenon in the area of the radiobiological effects has been described. A radiatio...

The Statistical Analysis of In-Vitro Chromosome Aberration Assay

The purpose of in-vitro chromosome aberration assay (ABS) is to determine whether the test compound is a clastogen which induces structural changes in chromosomes. The ABS belongs to the standard three test battery for genotoxicity testing for pharmaceuticals recommended by the fourth International Conference on Harmonisation (1997, Brussel). A full account of biological details of this assay c...